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The efficacy of autologous matrix-induced chondrogenesis (AMIC) for osteochondral lesions of the talus in the mid-long term: a systematic review and meta-analysis.
- Source :
- Journal of Orthopaedic Surgery & Research; 6/24/2024, Vol. 19 Issue 1, p1-12, 12p
- Publication Year :
- 2024
-
Abstract
- Purpose: The objective of this study was to provide a comprehensive review of the existing literature regarding the treatment of osteochondral lesions of the talus (OLT) using autologous matrix-induced chondrogenesis (AMIC), while also discussing the mid-long term functional outcomes, complications, and surgical failure rate. Methods: We searched Embase, PubMed, and Web of Science for studies on OLT treated with AMIC with an average follow-up of at least 2 years. Publication information, patient data, functional scores, surgical failure rate, and complications were extracted. Results: A total of 15 studies were screened and included, with 12 case series selected for meta-analysis and 3 non-randomized controlled studies chosen for descriptive analysis. The improvements in the Visual Analog Scale (VAS), the American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot, and Tegner scores at the last follow-up were (SMD = − 2.825, 95% CI − 3.343 to − 2.306, P < 0.001), (SMD = 2.73, 95% CI 1.60 to 3.86, P < 0.001), (SMD = 0.85, 95% CI 0.5 to 1.2, P < 0.001) respectively compared to preoperative values. The surgery failure rate was 11% (95% CI 8–15%), with a total of 12 patients experiencing complications. Conclusion: The use of AMIC demonstrates a positive impact on pain management, functional improvement, and mobility enhancement in patients with OLT. It is worth noting that the choice of stent for AMIC, patient age, and OLT size can influence the ultimate clinical outcomes. This study provides evidences supporting the safety and efficacy of AMIC as a viable treatment option in real-world medical practice. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANKLEBONE surgery
CARTILAGE cell transplantation
ANKLEBONE
MEDICAL information storage & retrieval systems
ARTICULAR cartilage
AUTOGRAFTS
VISUAL analog scale
FUNCTIONAL status
TREATMENT effectiveness
META-analysis
DESCRIPTIVE statistics
SURGICAL complications
SYSTEMATIC reviews
MEDLINE
CHONDROGENESIS
PAIN management
TREATMENT failure
ONLINE information services
CONFIDENCE intervals
CARTILAGE diseases
PHYSICAL mobility
Subjects
Details
- Language :
- English
- ISSN :
- 1749799X
- Volume :
- 19
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Orthopaedic Surgery & Research
- Publication Type :
- Academic Journal
- Accession number :
- 178065635
- Full Text :
- https://doi.org/10.1186/s13018-024-04864-z