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A near-infrared fluorescent probe for imaging peroxynitrite levels in paw edema mice and drug evaluation.

Authors :
Hu, Ling
Chen, Si-Si
Zhang, Hui
Chao, Jing-Jing
Peng, Zhen-Zhen
Mao, Guo-Jiang
Hu, Liufang
Ouyang, Juan
Min, Anjie
Li, Chun-Yan
Source :
Chemical Communications; 7/4/2024, Vol. 60 Issue 52, p6675-6678, 4p
Publication Year :
2024

Abstract

A near-infrared fluorescent probe (TX-P) for detecting peroxynitrite is constructed. The probe has a near-infrared emission (725 nm), large Stokes shift (125 nm) and excellent sensitivity and selectivity. In addition, TX-P can be used to visualize ONOO<superscript>−</superscript> in living cells, image ONOO<superscript>−</superscript> in paw edema mice and evaluate anti-inflammatory drugs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13597345
Volume :
60
Issue :
52
Database :
Complementary Index
Journal :
Chemical Communications
Publication Type :
Academic Journal
Accession number :
178068089
Full Text :
https://doi.org/10.1039/d4cc01562b