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Mechanisms and implications of podocyte autophagy in chronic kidney disease.
- Source :
- American Journal of Physiology: Renal Physiology; Jun2024, Vol. 326 Issue 6, pF877-F893, 17p
- Publication Year :
- 2024
-
Abstract
- Autophagy is a protective mechanism through which cells degrade and recycle proteins and organelles to maintain cellular homeostasis and integrity. An accumulating body of evidence underscores the significant impact of dysregulated autophagy on podocyte injury in chronic kidney disease (CKD). In this review, we provide a comprehensive overview of the diverse types of autophagy and their regulation in cellular homeostasis, with a specific emphasis on podocytes. Furthermore, we discuss recent findings that focus on the functional role of different types of autophagy during podocyte injury in chronic kidney disease. The intricate interplay between different types of autophagy and podocyte health requires further research, which is critical for understanding the pathogenesis of CKD and developing targeted therapeutic interventions. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHRONIC kidney failure
AUTOPHAGY
HOMEOSTASIS
Subjects
Details
- Language :
- English
- ISSN :
- 1931857X
- Volume :
- 326
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- American Journal of Physiology: Renal Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 178087505
- Full Text :
- https://doi.org/10.1152/ajprenal.00415.2023