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Mechanisms and implications of podocyte autophagy in chronic kidney disease.

Authors :
Njeim, Rachel
Merscher, Sandra
Fornoni, Alessia
Source :
American Journal of Physiology: Renal Physiology; Jun2024, Vol. 326 Issue 6, pF877-F893, 17p
Publication Year :
2024

Abstract

Autophagy is a protective mechanism through which cells degrade and recycle proteins and organelles to maintain cellular homeostasis and integrity. An accumulating body of evidence underscores the significant impact of dysregulated autophagy on podocyte injury in chronic kidney disease (CKD). In this review, we provide a comprehensive overview of the diverse types of autophagy and their regulation in cellular homeostasis, with a specific emphasis on podocytes. Furthermore, we discuss recent findings that focus on the functional role of different types of autophagy during podocyte injury in chronic kidney disease. The intricate interplay between different types of autophagy and podocyte health requires further research, which is critical for understanding the pathogenesis of CKD and developing targeted therapeutic interventions. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1931857X
Volume :
326
Issue :
6
Database :
Complementary Index
Journal :
American Journal of Physiology: Renal Physiology
Publication Type :
Academic Journal
Accession number :
178087505
Full Text :
https://doi.org/10.1152/ajprenal.00415.2023