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A function for CD2 on murine B cells?
- Source :
- Immunology & Cell Biology; Aug1997, Vol. 75 Issue 4, p333-339, 7p
- Publication Year :
- 1997
-
Abstract
- CD2 is expressed on murine B cells, probably as a result of a chromosomal translocation event during speciation. There are no activating antibodies to mouse CD2, but when activated non-specifically, only T cells up-regulate their expression of CD2. We investigated the expression and function of CD2 on B cells using mice transgenic for human CD2 under the control of a modified version of the autologous promoter/enhancer that included the immunoglobulin enhancer. This construction directs expression of human CD2 to the B cell compartment as well as to the T cell compartment. In this paper, we confirm that activating pairs of anti-CD2 monoclonal antibodies are mitogenic for mouse T cells transgenic for human CD2. In contrast, mouse B cells that express similar amounts of human CD2 are not stimulated to proliferate by equivalent doses of these antibodies. We were also unable to show any functional consequence for these B cells as a result of CD2 ligation. [ABSTRACT FROM AUTHOR]
- Subjects :
- B cells
CHROMOSOMES
T cells
MONOCLONAL antibodies
MITOGENS
IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 08189641
- Volume :
- 75
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Immunology & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 17809410
- Full Text :
- https://doi.org/10.1038/icb.1997.51