Association Between Plasma Anti-Factor Xa Concentrations and Large Artery Occlusion in Patients With Acute Ischemic Stroke Taking Direct Oral Anticoagulants for Non-valvular Atrial Fibrillation.

This letter to the editor published in the Annals of Laboratory Medicine discusses the association between low plasma concentrations of direct oral anticoagulants (DOACs) and an increased risk of large artery occlusion (LAO) in patients with acute ischemic stroke (AIS) and atrial fibrillation (AF). The study found that patients with LAOs had significantly lower DOAC plasma concentrations compared to patients without LAOs, regardless of whether they were administered at reduced doses. The findings suggest that monitoring plasma DOAC concentrations may help identify patients at risk of severe stroke. [Extracted from the article]