Data on Tumor Vaccines Detailed by Researchers at Anhui Medical University (Colloidal Hydrogel for Sensitizing Microwave Ablation-induced In Situ Tumor Vaccination and Modulating Innate and Adaptive Immunotherapy).

Researchers at Anhui Medical University in Hefei, China have developed a colloidal hydrogel that can sensitize microwave ablation-induced in situ tumor vaccination and modulate innate and adaptive immunotherapy. The hydrogel, made from gelatin nanoparticles and poly(acrylic acid)-calcium carbonate nanorods, delivers the microwave-sensitive agent sodium fluoride (NaF) to reverse the acidic and immunosuppressive tumor microenvironment. The hydrogel also incorporates anti-TIGIT monoclonal antibodies to enhance immune responses and improve tumor elimination. This study highlights the potential of colloidal hydrogel-sensitized microwave ablation therapy as a promising clinical strategy for in situ cancer vaccination. [Extracted from the article]