Back to Search Start Over

Trajectories of squamous cell carcinoma antigen and outcomes of patients with advanced penile cancer after chemotherapy based on paclitaxel, ifosfamid, and cisplatin regimen.

Authors :
Ma, Nan
Gan, Yi‐Xiang
Chao, Yin‐Yao
Liu, Zhen‐Hua
Chen, Xian‐Da
Yao, Kai
Han, Hui
Guo, Sheng‐Jie
Source :
Cancer Medicine; Jun2024, Vol. 13 Issue 12, p1-9, 9p
Publication Year :
2024

Abstract

Introduction: Penile cancer (PC) is a lethal malignancy with no effective prognostic biomarker. We aim to investigate associations between trajectories of squamous cell carcinoma antigen (SCC‐A) and patient outcomes after chemotherapy based on paclitaxel, ifosfamid, and cisplatin (TIP) regimen. Methods: Consecutive AJCC staging III/IV PC patients who received TIP chemotherapy and repeated SCC‐A measurements in 2014–2022 were analyzed. Latent class growth mixed (LCGM) models were employed to characterize patients' serum SCC‐A trajectories. Patient survival, and clinical and pathological tumor responses were compared. Inverse probability treatment weighting was used to adjust confounding factors. Results: Eighty patients were included. LCGM models identified two distinct trajectories of SCC‐A: low‐stable (40%; n = 32) and high‐decline (60%; n = 48). Overall survival (HR [95% CI]: 3.60 [1.23–10.53], p = 0.019), progression‐free survival (HR [95% CI]: 11.33 [3.19–40.3], p < 0.001), objective response rate (37.5% vs. 62.5% p = 0.028), disease control rate (60.4% vs. 96.9% p < 0.00), and pathological complete response rate (21.2% vs. 51.9%, p = 0.014) were significantly worse in the high‐decline arm. Conclusion: PC patients' SCC‐A change rate was associated with tumor response and patient survival after TIP chemotherapy. SCC‐A might assist tumor monitoring after systemic therapies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20457634
Volume :
13
Issue :
12
Database :
Complementary Index
Journal :
Cancer Medicine
Publication Type :
Academic Journal
Accession number :
178131370
Full Text :
https://doi.org/10.1002/cam4.7353