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Association between colonic adenoma size and proliferative zone in the crypt.
- Source :
- Scandinavian Journal of Gastroenterology; Jul2024, Vol. 59 Issue 7, p875-879, 5p
- Publication Year :
- 2024
-
Abstract
- We previously reported unusual adenomas with proliferative zones confined to the lower two-thirds of the crypt. The proliferative zones of colorectal adenomas have three patterns: 'lower,' 'superficial' and 'entire'. This study aimed to clarify the characteristics of each adenoma pattern. We investigated 2925 consecutive patients who underwent colonoscopy at our institute. All polyps that were removed were histologically examined using hematoxylin and eosin staining. The location of the proliferative zone was assessed for adenomas. Data were compared using Dunn's and Kruskal–Wallis tests. Colorectal adenomas with 'lower' proliferative zone often appeared similar to hyperplastic polyps (42.8%), and the frequency was significantly higher than that of adenomas with 'superficial' and 'entire' proliferative zones (p < 0.001). The mean sizes of adenomas were 2.4, 3.0 and 3.9 mm for 'lower,' 'superficial' and 'entire' proliferative zones, respectively. A significant gradual increase was observed. Regarding morphology, the proportion of type 0–I in adenomas with an 'entire' proliferative zone was significantly higher than that in adenomas with 'superficial' proliferative zone (p < 0.001). While colorectal adenomas develop and increase in size, the proliferative zone appears to shift upward and become scattered. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEMATOXYLIN & eosin staining
ADENOMA
KRUSKAL-Wallis Test
Subjects
Details
- Language :
- English
- ISSN :
- 00365521
- Volume :
- 59
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 178152172
- Full Text :
- https://doi.org/10.1080/00365521.2024.2345385