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The Role of Zinc in the Development of Vascular Dementia and Parkinson's Disease and the Potential of Carnosine as Their Therapeutic Agent.
- Source :
- Biomedicines; Jun2024, Vol. 12 Issue 6, p1296, 16p
- Publication Year :
- 2024
-
Abstract
- Synaptic zinc ions (Zn<superscript>2+</superscript>) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the current comprehension of the Zn<superscript>2+</superscript>-induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn<superscript>2+</superscript>-induced neurotoxicity was investigated by using immortalised hypothalamic neurons (GT1-7 cells). This cell line is useful for the development of a rapid and convenient screening system for investigating Zn<superscript>2+</superscript>-induced neurotoxicity. GT1-7 cells were also used to search for substances that prevent Zn<superscript>2+</superscript>-induced neurotoxicity. Among the tested substances was a protective substance in the extract of Japanese eel (Anguilla japonica), and we determined its structure to be like carnosine (β-alanylhistidine). Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn<superscript>2+</superscript>-induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22279059
- Volume :
- 12
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Biomedicines
- Publication Type :
- Academic Journal
- Accession number :
- 178160930
- Full Text :
- https://doi.org/10.3390/biomedicines12061296