Animal and Cellular Models of Alzheimer's Disease.

This document is an editorial from the journal Biomedicines that focuses on animal and cellular models of Alzheimer's disease (AD). The editorial highlights the importance of these models in understanding the pathogenic mechanisms of AD and developing clinical applications and therapies. The document discusses key pathological processes in AD, including vascular damage, myelinization, sex differences, and metabolic alterations. It also presents several studies that investigate the role of brain vasculature, astrocytes, microglia, sex differences, and lipid composition in AD. The editorial concludes that these studies contribute to a better understanding of AD pathology and may guide the development of effective therapies. [Extracted from the article]