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Can silver nanoparticles stabilized by Fenugreek (Trigonella foenm-graecum) improve tibial bone defects repair in rabbits? A preliminary study.
- Source :
- Open Veterinary Journal; 2024, Vol. 14 Issue 5, p1281-1293, 13p
- Publication Year :
- 2024
-
Abstract
- Background: A fracture is considered a medical emergency leading to considerable complications. Aim: This study aimed to describe the accelerating action of Ag-NPs-FG on fracture healing in rabbits. Methods: Silver NPs (AgNPs) were reduced with fenugreek (FG), loaded into a starch gel base, and investigated for their morphology, size, and charge. Four equal groups were randomly formed of 40 adult male rabbits. A 3.5 mm diameter bone defect was created at the proximal metaphysis of the right tibia in each rabbit. Groups 1-4 were injected with placebo saline, AgNPs-FG, plain gel, and FG-gel at the bone defect zone, respectively. The healing was assessed for 8 weeks postoperatively based on the radiographic, bone turnover markers, and histopathological examinations. Results: The AgNPs-FG was obtained as a faint reddish color, spherical in shape, with an absorbance of 423 nm, a size of 118.0 ± 1.7 nm, and a surface charge of -7.8 ± 0.518 mV. The prepared AgNPs-FG hydrogel was clear, translucent, and homogenous. The pH values were 6.55-6.5 ± 0.2, the viscosity of 4,000 and 1,875 cPs, and spreadability of 1.6 ± 0.14 and 2.0 ± 0.15 for both FG and AgNPs-FG hydrogel, respectively. The radiographic union scale was significantly (p < 0.05) improved in group 2 with a significant (p < 0.05) increase in bone turnover markers was found in comparison to other treated groups. Histopathological examination revealed the formation of mature bone on the 28th postoperative day in groups 2 and 4. Conclusion: Colloidal nano-formulation of AgNPs-FG loaded hydrogel could be a promising formulation to accelerate rabbits' tibial bone healing process. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22264485
- Volume :
- 14
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Open Veterinary Journal
- Publication Type :
- Academic Journal
- Accession number :
- 178170630
- Full Text :
- https://doi.org/10.5455/OVJ.2024.v14.i5.23