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Supplemental Psyllium Fiber Increases Antimicrobial Proteins via the Tuft Cell-ILC2 Circuit and Type II Immune Response in the Mouse Small Intestine.
- Source :
- Nutraceuticals (1661-3821); Jun2024, Vol. 4 Issue 2, p307-322, 16p
- Publication Year :
- 2024
-
Abstract
- Dietary fibers regulate intestinal barrier function; however, the precise mechanisms remain unclear. This study investigated the effects of psyllium fibers on antimicrobial protein expression, focusing on the type II immunity and tuft cell-group 2 innate lymphoid cell (ILC2) circuit in the small intestine of the mouse. Supplemental psyllium fiber upregulated antimicrobial proteins, such as small proline-rich protein 2A (SPRR2A) and resistin-like beta (RELMĪ²), in mouse small intestine, evidently affecting cecal microbiota composition. The psyllium fibers also increased the RNA and protein expression of molecules related to ILC2 and tuft cells, such as IL-13, IL-25, DCLK1, Gfi-1b, SH2 domain-containing protein 3C, and Spi-B. In addition, ILC2 inhibitor (disulfiram) and bitter taste receptor blocker administration reduced psyllium-induced SPRR2A and RELMĪ² expression. Collectively, psyllium supplementation upregulates antimicrobial proteins such as SPRR2A and RELMß via the type II immune response and tuft cell-ILC2 circuit in the mouse small intestine. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- Volume :
- 4
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Nutraceuticals (1661-3821)
- Publication Type :
- Academic Journal
- Accession number :
- 178184147
- Full Text :
- https://doi.org/10.3390/nutraceuticals4020019