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The effect of fasting plasma glucose on in-hospital mortality after acute myocardial infarction in patients with and without diabetes: findings from a prospective, nationwide, and multicenter registry.
- Source :
- Journal of Geriatric Cardiology; May2024, Vol. 21 Issue 5, p523-533, 11p
- Publication Year :
- 2024
-
Abstract
- OBJECTIVES To evaluate the predictive value of fasting plasma glucose (FPG) for in-hospital mortality in patients with acute myocardial infarction (AMI) with different glucose metabolism status. METHODS We selected 5,308 participants with AMI from the prospective, nationwide, multicenter CAMI registry, of which 2,081 were diabetic and 3,227 were nondiabetic. Patients were divided into high FPG and low FPG groups according to the optimal cutoff values of FPG to predict in-hospital mortality for diabetic and nondiabetic cohorts, respectively. The primary endpoint was in-hospital mortality. RESULTS Overall, 94 diabetic patients (4.5%) and 131 nondiabetic patients (4.1%) died during hospitalization, and the optimal FPG thresholds for predicting in-hospital death of the two cohorts were 13.2 mmol/L and 6.4 mmol/L, respectively. Compared with individuals who had low FPG, those with high FPG were significantly associated with higher in-hospital mortality in diabetic cohort (10.1% vs. 2.8%; odds ratio [OR] = 3.862, 95% confidence interval [CI]: 2.542–5.869) and nondiabetic cohort (7.4% vs. 1.7%; HR = 4.542, 95%CI: 3.041–6.782). After adjusting the potential confounders, this significant association was not changed. Furthermore, FPG as a continuous variable was positively associated with in-hospital mortality in single-variable and multivariable models regardless of diabetic status. Adding FPG to the original model showed a significant improvement in C-statistic and net reclassification in diabetic and nondiabetic cohorts. CONCLUSIONS This large-scale registry indicated that there is a strong positive association between FPG and in-hospital mortality in AMI patients with and without diabetes. FPG might be useful to stratify patients with AMI. [ABSTRACT FROM AUTHOR]
- Subjects :
- MYOCARDIAL infarction
PREDICTIVE tests
PEARSON correlation (Statistics)
ACUTE diseases
T-test (Statistics)
DATA analysis
RECEIVER operating characteristic curves
SECONDARY analysis
GLYCOSYLATED hemoglobin
RESEARCH funding
FISHER exact test
MULTIPLE regression analysis
PROBABILITY theory
HOSPITAL mortality
DESCRIPTIVE statistics
MANN Whitney U Test
CHI-squared test
MULTIVARIATE analysis
BLOOD sugar
LONGITUDINAL method
ODDS ratio
RESEARCH
STATISTICS
COMPARATIVE studies
CONFIDENCE intervals
DATA analysis software
DIABETES
FASTING
SENSITIVITY & specificity (Statistics)
Subjects
Details
- Language :
- English
- ISSN :
- 16715411
- Volume :
- 21
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Geriatric Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 178258570
- Full Text :
- https://doi.org/10.26599/1671-5411.2024.05.008