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Alterations in brain morphology and functional connectivity mediate cognitive decline in carotid atherosclerotic stenosis.
- Source :
- Frontiers in Aging Neuroscience; 2024, p1-12, 12p
- Publication Year :
- 2024
-
Abstract
- Background: Patients with carotid atherosclerotic stenosis (CAS) often have varying degrees of cognitive decline. However, there is little evidence regarding how brain morphological and functional abnormalities impact the cognitive decline in CAS patients. This study aimed to determine how the brain morphological and functional changes affected the cognitive decline in patients with CAS. Methods: The brain morphological differences were analyzed using surface and voxel-based morphometry, and the seed-based whole-brain functional connectivity (FC) abnormalities were analyzed using resting-state functional magnetic resonance imaging. Further, mediation analyses were performed to determine whether and how morphological and FC changes affect cognition in CAS patients. Results: The CAS-MCI (CAS patients with mild cognitive impairment) group performed worse in working memory, verbal fluency, and executive time. Cortical thickness (CT) of the left postcentral and superiorparietal were significantly reduced in CAS-MCI patients. The gray matter volume (GMV) of the right olfactory, left temporal pole (superior temporal gyrus) (TPOsup.L), left middle temporal gyrus (MTG.L), and left insula (INS.L) were decreased in the CAS-MCI group. Besides, decreased seed-based FC between TPOsup.L and left precuneus, between MTG.L and TPOsup.L, and between INS.L and MTG.L, left middle frontal gyrus, as well as Superior frontal gyrus, were found in CAS-MCI patients. Mediation analyses demonstrated that morphological and functional abnormalities fully mediated the association between the maximum degree of carotid stenosis and cognitive function. Conclusion: Multiple brain regions have decreased GMV and CT in CAS-MCI patients, along with disrupted seed-based FC. These morphological and functional changes play a crucial role in the cognitive impairment in CAS patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- CAROTID artery radiography
STATISTICAL correlation
FUNCTIONAL connectivity
MILD cognitive impairment
ACADEMIC medical centers
T-test (Statistics)
BRAIN
BLOOD vessels
COMPUTED tomography
FISHER exact test
SEX distribution
HYPERTENSION
SMOKING
CAROTID artery stenosis
MAGNETIC resonance imaging
DESCRIPTIVE statistics
MANN Whitney U Test
AGE distribution
CAROTID artery diseases
NEUROPSYCHOLOGICAL tests
RESEARCH
MEMORY
FACTOR analysis
DATA analysis software
COMPARATIVE studies
ALCOHOL drinking
EDUCATIONAL attainment
DIABETES
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 16634365
- Database :
- Complementary Index
- Journal :
- Frontiers in Aging Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 178268310
- Full Text :
- https://doi.org/10.3389/fnagi.2024.1395911