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Factors associated with cognitive function in patient with Alzheimer's disease with newly prescribed acetylcholinesterase inhibitors: A 1‐year retrospective cohort study.
- Source :
- Aging Medicine; Jun2024, Vol. 7 Issue 3, p312-319, 8p
- Publication Year :
- 2024
-
Abstract
- Objective: We aimed to examine the factors associated with treatment outcomes in patients with Alzheimer's disease (AD) after 1 year of acetylcholinesterase inhibitors (AChEI) treatment. Method: We obtained electronic medical records from a medical center in Southern Taiwan between January 2015 and September 2021. Participants aged ≥60 who were newly diagnosed with AD and had been prescribed AChEIs were included. Cognitive assessments were performed before the AChEIs were prescribed and at the 1 year follow‐up. Cognition progressors were defined as a Mini‐Mental State Examination decline of >3 or a Clinical Dementia Rating decline of ≥1 after 1 year of AChEI treatment. The relationship between the baseline characteristics and cognitive status after follow‐up was investigated using logistic regression analysis after adjusting for potential confounders. Results: A total of 1370 patients were included in our study (mean age, 79.86 ± 8.14 years). After adjustment, the body mass index (BMI) was found to be significantly lower in the progressor group [adjusted odds ratio (AOR): 0.970, 95% confidence intervals (95% CIs): 0.943 to 0.997, P = 0.033]. The usage of antipsychotics was significantly higher in the progressor group (AOR: 1.599, 95% CIs: 1.202 to 2.202, P = 0.001). The usage of benzodiazepine receptor agonists also tended to be significantly higher in the progressor group (AOR: 1.290, 95% CIs: 0.996 to 1.697, p = 0.054). Conclusion: These results suggest that patients with AD who receive 1 year of AChEI treatment and have a lower BMI or concurrent treatment with antipsychotics and benzodiazepine receptor agonists are more likely to suffer from cognitive decline. [ABSTRACT FROM AUTHOR]
- Subjects :
- COGNITION disorder risk factors
RISK assessment
BENZODIAZEPINES
ALZHEIMER'S disease
CHOLINESTERASE inhibitors
DATA analysis
BODY mass index
QUESTIONNAIRES
LOGISTIC regression analysis
TREATMENT effectiveness
RETROSPECTIVE studies
ANTIPSYCHOTIC agents
TRANQUILIZING drugs
LONGITUDINAL method
ODDS ratio
STATISTICS
NEUROPSYCHOLOGICAL tests
CONFIDENCE intervals
COGNITION
PSYCHOSOCIAL factors
Subjects
Details
- Language :
- English
- ISSN :
- 24750360
- Volume :
- 7
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Aging Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 178279732
- Full Text :
- https://doi.org/10.1002/agm2.12324