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Elevated VEGF-A Levels in the Aqueous Humor of Patients With Primary Open Angle Glaucoma.
- Source :
- In Vivo; Jul/Aug2024, Vol. 38 Issue 4, p1875-1881, 7p
- Publication Year :
- 2024
-
Abstract
- Background/Aim: The purpose of the current study was to compare the vascular endothelial growth factor-A (VEGF-A) levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and non-glaucomatous eyes and reveal any potential statistically significant correlations. Patients and Methods: This was an observational cross-sectional study. Aqueous humor samples (50-100 µl) were collected under aseptic conditions, from the anterior chamber at the start of glaucoma or cataract surgery. The levels of VEGF-A were measured using a multiplex bead-based immunoassay. Results: Aqueous humor samples were obtained from 76 participants: 39 with POAG and 36 with age-related cataracts as controls. VEGF-A levels were significantly elevated in the POAG group (166.37±110.04 pg/ml, p=0.011) compared to the control group (119.02±49.09 pg/ml). The receiver operating characteristic (ROC) analysis showed that VEGF-A had significant prognostic ability for POAG (AUC=0.67; p=0.006). An optimal cut-off for VEGF-A was found to be 148.5 pg/ml with a sensitivity of 54%, specificity of 81.1%, positive prognostic value (PPV) of 75% and negative prognostic value (NPV) of 62.5%. Logistic regression analysis showed that after adjusting for sex and age, patients with VEGF-A higher than 148.5 pg/ml had almost 10 times greater likelihood for POAG. Conclusion: VEGF-A is elevated in patients with POAG and can potentially have a prognostic ability for these patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0258851X
- Volume :
- 38
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- In Vivo
- Publication Type :
- Academic Journal
- Accession number :
- 178290047
- Full Text :
- https://doi.org/10.21873/invivo.13642