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Vein of Marshall chemical ablation decreases atrial fibrillation drivers detected by CARTOFINDER.
- Source :
- Journal of Cardiovascular Electrophysiology; Jul2024, Vol. 35 Issue 7, p1461-1470, 10p
- Publication Year :
- 2024
-
Abstract
- Introduction: This study sought to elucidate the impact of vein of Marshall (VOM) chemical ablation on atrial fibrillation (AF) drivers by investigating the changes in CARTOFINDER mappings before and after VOM chemical ablation in patients with persistent AF. Methods: This study included 23 consecutive patients undergoing catheter ablation for long‐persistent AF (>18 months). VOM chemical ablation was performed following pulmonary vein isolation. CARTOFINDER and AF cycle length (AFCL) maps were created in the left atrium (LA) before and after VOM chemical ablation. The LA was divided into 8 segments, and the number of focal activation points with 6 or more repetitions was counted in each segment. Results: The number of focal activation points was largest in the LA appendage (LAA). After VOM chemical ablation, the number of focal activation points in the LA decreased significantly (37 [interquartile range, IQR: 19–55] vs. 15 [IQR: 7–21], p <.001), and median AFCL was significantly prolonged (159 [147–168] vs. 164 [150–173] ms, p <.001). In the assessment of each segment, significant decreases in focal activation points were observed in the inferior, lateral, and anterior segments and LAA. Among the focal activation points disappearing after chemical ablation, the number in the non‐ethanol‐affected area was significantly larger than that in the affected area (13 [8–25] vs. 4 [1–10], p <.001). Conclusions: VOM chemical ablation decreases AF drivers detected by CARTOFINDER. Mechanisms other than direct myocardial damage are considered to contribute the attenuation of AF drivers. [ABSTRACT FROM AUTHOR]
- Subjects :
- ATRIAL fibrillation diagnosis
PUBLIC hospitals
PREDICTIVE tests
PULMONARY veins
LEFT heart atrium
HEART function tests
BODY surface mapping
TREATMENT effectiveness
DESCRIPTIVE statistics
MANN Whitney U Test
HEART beat
ATRIAL fibrillation
ANALYSIS of variance
CATHETER ablation
DISEASE relapse
AUTOMATION
DATA analysis software
TIME
ALGORITHMS
Subjects
Details
- Language :
- English
- ISSN :
- 10453873
- Volume :
- 35
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of Cardiovascular Electrophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 178395186
- Full Text :
- https://doi.org/10.1111/jce.16311