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Characterization of metabolites of sagittatoside B in rats using UPLC-QTOF-MS spectrometry.
- Source :
- Natural Product Research; Jul2024, Vol. 38 Issue 13, p2272-2281, 10p
- Publication Year :
- 2024
-
Abstract
- Sagittatoside B is one of the principal diglucosides in Herba Epimedii. In this work, an ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS) was applied to the rapid analysis of sagittatoside B metabolites in rats after oral administration. A total number of 17 metabolites were detected or tentatively identified from rat plasma, bile, urine and feces. The major metabolic pathways of sagittatoside B in rats were hydrolysis, hydrogenation, hydroxylation, dehydrogenation, demethylation, decarbonylation and conjugation with glucuronic acid and different sugars. This work revealed the metabolism of sagittatoside B in vivo, and reported the characteristic metabolic reactions of sagittatoside B for the first time. This provided the basis for the further research and development of sagittatoside B, and also provided reference for the metabolism of active flavonoid compounds. [ABSTRACT FROM AUTHOR]
- Subjects :
- ORAL drug administration
METABOLITES
RATS
SPECTROMETRY
GLUCURONIC acid
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 38
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 178419705
- Full Text :
- https://doi.org/10.1080/14786419.2023.2172006