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Current status of diagnostic assays for emerging zoonotic viruses: Nipah and Hendra.

Authors :
Sharma, Nancy
Jamwal, Vijay Lakshmi
Nagial, Sakshi
Ranjan, Manish
Rath, Dharitri
Gandhi, Sumit G.
Source :
Expert Review of Molecular Diagnostics; Jun2024, Vol. 24 Issue 6, p473-485, 13p
Publication Year :
2024

Abstract

Nipah and Hendra viruses belong to the Paramyxoviridae family, which pose a significant threat to human health, with sporadic outbreaks causing severe morbidity and mortality. Early symptoms include fever, cough, sore throat, and headache, which offer little in terms of differential diagnosis. There are no specific therapeutics and vaccines for these viruses. This review comprehensively covers a spectrum of diagnostic techniques for Nipah and Hendra virus infections, discussed in conjunction with appropriate type of samples during the progression of infection. Serological assays, reverse transcriptase Real-Time PCR assays, and isothermal amplification assays are discussed in detail, along with a listing of few commercially available detection kits. Patents protecting inventions in Nipah and Hendra virus detection are also covered. Despite several outbreaks of Nipah and Hendra infections in the past decade, in-depth research into their pathogenesis, Point-of-Care diagnostics, specific therapies, and human vaccines is lacking. A prompt and accurate diagnosis is pivotal for efficient outbreak management, patient treatment, and the adoption of preventative measures. The emergence of rapid point-of-care tests holds promise in enhancing diagnostic capabilities in real-world settings. The patent landscape emphasizes the importance of innovation and collaboration within the legal and business realms. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14737159
Volume :
24
Issue :
6
Database :
Complementary Index
Journal :
Expert Review of Molecular Diagnostics
Publication Type :
Academic Journal
Accession number :
178477823
Full Text :
https://doi.org/10.1080/14737159.2024.2368591