Reply to: Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut.

The article is a response to a previous study that inaccurately predicted the diversity of archaeal viruses in the human gut. The authors of the response explain that the computational tools used in the previous study were limited in identifying novel archaeal viral sequences because they were developed based on reference viral genomes available in public databases. The authors conducted their own analysis using different computational tools and found a great discrepancy in the results. They categorized the sequences in the database into five levels of confidence based on the results of various bioinformatic tools. They also provided a modified figure to visually demonstrate the novel contributions of the database in enhancing archaeal virus detection and classification. The authors advise using only the sequences classified as "Complete Viruses" and "High Confidence Viruses" from the database for accuracy and reliability. [Extracted from the article]