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Investigators at Okayama University Report Findings in Allergic Conjunctivitis (Evaluation Methods Using Tear Volume In a Conjunctivitis Mice Model).

Source :
Drug Week; 7/22/2024, p976-976, 1p
Publication Year :
2024

Abstract

A recent study conducted by investigators at Okayama University in Japan focused on developing quantitative evaluation methods for allergic conjunctivitis, an immune-mediated inflammatory disease of the conjunctiva. The researchers used a mice model to evaluate tear volume as an indicator of conjunctivitis, and they found that tear volume increased in response to antigen-induced conjunctivitis as well as direct instillation of histamine, compound 48/80, and carrageenan. They also discovered that levocabastine inhibited the increase in tear volume in antigen-induced allergic conjunctivitis and histamine- and compound 48/80-induced conjunctivitis models, while betamethasone only suppressed carrageenan-induced tear volume. The researchers concluded that tear volume evaluation in a conjunctivitis mice model is a highly quantitative and useful index for evaluating drug efficacy. [Extracted from the article]

Details

Language :
English
ISSN :
15316440
Database :
Complementary Index
Journal :
Drug Week
Publication Type :
Periodical
Accession number :
178507989