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Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography.
- Source :
- Nature Communications; 7/26/2024, Vol. 15 Issue 1, p1-11, 11p
- Publication Year :
- 2024
-
Abstract
- Electrocorticography is an established neural interfacing technique wherein an array of electrodes enables large-area recording from the cortical surface. Electrocorticography is commonly used for seizure mapping however the implantation of large-area electrocorticography arrays is a highly invasive procedure, requiring a craniotomy larger than the implant area to place the device. In this work, flexible thin-film electrode arrays are combined with concepts from soft robotics, to realize a large-area electrocorticography device that can change shape via integrated fluidic actuators. We show that the 32-electrode device can be packaged using origami-inspired folding into a compressed state and implanted through a small burr-hole craniotomy, then expanded on the surface of the brain for large-area cortical coverage. The implantation, expansion, and recording functionality of the device is confirmed in-vitro and in porcine in-vivo models. The integration of shape actuation into neural implants provides a clinically viable pathway to realize large-area neural interfaces via minimally invasive surgical techniques. Large area electrocorticography is limited by invasive craniotomies. Here, the authors combine soft robotic bioelectronics with origami inspired packaging to create a minimally invasive electrocorticography array. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 15
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- 178622325
- Full Text :
- https://doi.org/10.1038/s41467-024-50597-2