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Delayed-Type Hypersensitivity in the Mouse II. Transfer by Thymus-Derived (T) Cells.
- Source :
- Scandinavian Journal of Immunology; 1972, Vol. 1 Issue 3, p237-245, 9p, 6 Charts, 2 Graphs
- Publication Year :
- 1972
-
Abstract
- Delayed-type hypersensitivity (DTH) to <em>Salmonella</em> polymerized flagellin (POL) was transferred to normal and Iethally irradiated CBA mice by POL-activated thymus-derived (T) cells or by lymphoid cells rich in T cells from POL-primed donors, but <em>not</em> by POL-activated bone marrow-derived (B) cells or by serum from POL-primed donors. It was therefore concluded that T cells play a key role in the initiation of DTH reactions. T cells activated by POL of one specificity were equally able to transfer DTH to POL of the same or of another specificity. DTH to haemocyanin (HCY) (<em>Jasus lalandii</em>) was transferred only by HCY-activated T cells. Two interpretations of these findings are discussed: 1) that T cells may be less restricted in specificity than B cells, and 2) that T cells recognize a common antigenic determinant (carrier determinant) on the polymerized flagellins of <em>Salmonella spp</em>. which is not recognized by B cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- DELAYED hypersensitivity
CELLS
THYMUS
LYMPHOID tissue
BONE marrow
T cells
Subjects
Details
- Language :
- English
- ISSN :
- 03009475
- Volume :
- 1
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 17862579
- Full Text :
- https://doi.org/10.1111/j.1365-3083.1972.tb01815.x