Editorial: Untangle the broad connections and tight interactions between human microbiota and complex diseases through data-driven approaches, volume II.

This editorial, published in Frontiers in Microbiology in July 2024, emphasizes the importance of data-driven approaches in understanding the relationship between human microbiota and complex diseases. The human microbiota, consisting of trillions of microorganisms in the body, plays a significant role in maintaining health and influencing disease states. Traditional statistical methods are insufficient for analyzing the vast amount of data generated from microbiota analysis, necessitating the use of advanced data-driven approaches like bioinformatics and machine learning. The editorial highlights the growing use of these techniques and their potential for improving diagnostics, treatments, and prevention strategies for complex diseases. The document also mentions specific research articles published in the same issue that investigate the causal associations between microbiota and various complex diseases using Mendelian randomization investigations. The articles cover a wide range of topics, including the relationship between gut microbiome and conditions such as psoriatic arthritis, androgenetic alopecia, and hemorrhagic stroke. Other articles focus on the development and evaluation of computational models for predicting microbe-disease associations. The document expresses gratitude to the contributors and reviewers of the research articles, and funding sources and potential conflicts of interest are disclosed. [Extracted from the article]