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Synthesis of Transparent Bacterial Cellulose Films as a Platform for Targeted Drug Delivery in Wound Care.

Authors :
Amorim, Julia Didier Pedrosa de
Cavalcanti, Yasmim de Farias
Medeiros, Alexandre D'Lamare Maia de
Silva Junior, Cláudio José Galdino da
Durval, Italo José Batista
Costa, Andréa Fernanda de Santana
Sarubbo, Leonie Asfora
Source :
Processes; Jul2024, Vol. 12 Issue 7, p1282, 21p
Publication Year :
2024

Abstract

Bacterial cellulose (BC) can be chemically modified and combined with other materials to create composites with enhanced properties. In the medical field, biomaterials offer advantages, such as biocompatibility and sustainability, enabling improved therapeutic strategies and patient outcomes. Incorporating lidocaine into wound dressings offers significant potential benefits. In this study, transparent BC films were produced in situ with an undefined minimal culture medium with a yeast and bacteria co-culture system on black tea (Camellia sinensis) and white sugar medium for three days. Lidocaine was incorporated ex situ into the BC matrix, and the composite film was sterilized using gamma radiation. Drug-release studies showed a two-stage release profile, with an initial fast release (24.6%) followed by a slower secondary release (27.2% cumulative release). The results confirmed the incorporation of lidocaine into the BC, producing highly transparent films with excellent thermal stability, essential for the storage and transportation of wound dressings. This study highlighted BC properties and drug incorporation and release behavior. The findings contribute towards optimizing wound dressings with controlled drug release, showcasing the potential of transparent BC films as an effective platform for wound care and drug-delivery applications. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22279717
Volume :
12
Issue :
7
Database :
Complementary Index
Journal :
Processes
Publication Type :
Academic Journal
Accession number :
178688920
Full Text :
https://doi.org/10.3390/pr12071282