The limitations of evidence-based medicine compel the practice of personalized medicine.

The article discusses the limitations of evidence-based medicine in the critical care environment and the need for personalized medicine. It highlights the challenges faced by critical care physicians in making decisions based on available evidence, such as the vast amount of literature, outdated information, and the difficulty in conducting high-quality trials. The article also emphasizes the importance of expert judgment and experience in making ad-hoc decisions when evidence is lacking. It suggests that a deeper understanding of disease mechanisms and the development of more targeted therapies may lead to more effective personalized medicine in the future. [Extracted from the article]