Back to Search Start Over

Real-world analysis of brain atrophy in multiple sclerosis patients with an artificial intelligence based software tool.

Authors :
Reinhardt, Caroline
Angstwurm, Klemens
Freudenstein, David
Lee, De-Hyung
Wendl, Christina
Linker, Ralf A.
Source :
Neurological Research & Practice; 8/8/2024, Vol. 6 Issue 1, p1-9, 9p
Publication Year :
2024

Abstract

Background: Atrophy of white and grey matter volumes occurs early in the brains of people with multiple sclerosis (pwMS) and has great clinical relevance. In clinical trials, brain atrophy can be quantified by magnetic resonance imaging (MRI) with automated software tools. Methods: In this study, we analyze volumes of various brain regions with the software "md brain" based on routine MRI scans of 53 pwMS in a real-world setting. We compare brain volumes of pwMS with an EDSS ≥ 3.5 and a disease duration ≥ 10 years to the brain volumes of pwMS with an EDSS < 3.5 and a disease duration < 10 years as well as with or without immunotherapy. Results: pwMS with an EDSS ≥ 3.5 and a disease duration ≥ 10 years had significantly lower volumes of the total brain, the grey matter and of the frontal, temporal, parietal and occipital lobe regions as compared to pwMS with an EDSS < 3.5 and a disease duration < 10 years. Regional brain volumes were significantly lower in pwMS without immunotherapy. Conclusions: The study showed that higher EDSS, longer disease duration and absence of immunotherapy was associated with lower volumes in a number of brain regions. Further real-world studies may include larger patient cohorts in longitudinal analyses. [ABSTRACT FROM AUTHOR]

Details

Language :
English
Volume :
6
Issue :
1
Database :
Complementary Index
Journal :
Neurological Research & Practice
Publication Type :
Academic Journal
Accession number :
178878481
Full Text :
https://doi.org/10.1186/s42466-024-00339-y