The new life of ibrutinib therapy in CLL: enhancing personalized approaches.

The article discusses the use of ibrutinib therapy in the treatment of chronic lymphocytic leukemia (CLL). It highlights the shift from chemo-immunotherapy to targeted therapy, specifically Bruton's tyrosine kinase (BTK) inhibitors like ibrutinib. The article emphasizes the long-term outcomes and benefits of ibrutinib, particularly for patients with TP53 mutations. It also addresses concerns about the safety profile of ibrutinib, including cardiovascular events. The article presents real-world studies that demonstrate improvements in the management of adverse events and retention rates with ibrutinib. It suggests that dose reduction of ibrutinib can optimize treatment outcomes without compromising efficacy. The article concludes by emphasizing the need for a personalized and patient-centered approach to CLL treatment, integrating real-world insights, proactive management strategies, and patient-reported outcomes. [Extracted from the article]