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Cytoprotection as an Innovative Therapeutic Strategy to Cardiogenic Shock: Exploring the Potential of Cytidine-5-Diphosphocholine to Mitigate Target Organ Damage.

Authors :
González-Pacheco, Héctor
Amezcua-Guerra, Luis Manuel
Franco, Martha
Arias-Mendoza, Alexandra
Ortega-Hernández, Jorge A.
Massó, Felipe
Source :
Journal of Vascular Research; 2024, Vol. 61 Issue 4, p160-165, 6p
Publication Year :
2024

Abstract

Background: Preservation of organ function and viability is a crucial factor for survival in cardiogenic shock (CS) patients. There is not information enough on cytoprotective substances that may delay organs damage in CS. We hypothesize that cytidine-5-diphosphocholine (CDP-choline) can act as a cytoprotective pharmacological measure that diminishes the target organ damage. So, we aimed to perform a review of works carried out in our institution to evaluate the effect of therapeutic cytoprotection of the CDP-choline. Summary: CDP-choline is an intermediate metabolite in the synthesis of phosphatidylcholine. It is also a useful drug for the treatment of acute ischaemic stroke, traumatic brain injury, and neurodegenerative diseases and has shown an excellent pharmacological safety profile as well. We review our institution's work and described the cytoprotective effects of CDP-choline in experimental models of heart, liver, and kidney acute damage, where this compound was shown to diminish reperfusion-induced ventricular arrhythmias, oxidative stress, apoptotic cell death, inflammation, lactic acid levels and to preserve mitochondrial function. Key Messages: We propose that additional research is needed to evaluate the impact of cytoprotective therapy adjuvant to mitigate target organ damage in patients with CS. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10181172
Volume :
61
Issue :
4
Database :
Complementary Index
Journal :
Journal of Vascular Research
Publication Type :
Academic Journal
Accession number :
178910917
Full Text :
https://doi.org/10.1159/000538946