Shandong Provincial Hospital Affiliated to Shandong First Medical University Researcher Highlights Recent Research in Neuromyelitis Optica (Identification of neurotransmitter imbalances in the cingulate cortex of NMOSD patients using magnetic...).

A recent report discusses research on neuromyelitis optica (NMO), a neurological disorder that affects the central nervous system. The study focused on the association between neurotransmitter imbalances and cognitive deficits in NMO patients. The researchers used magnetic resonance spectroscopy to evaluate levels of gamma-aminobutyric acid (GABA), glutamate, and glutathione in different regions of the brain. The results showed that NMO patients had decreased GABA levels and increased glutamate, glutathione, and excitation/inhibition ratio in certain brain regions. These findings suggest that dysregulation in the GABAergic and glutamatergic systems may contribute to emotional disorders and cognitive decline in NMO patients. The study also highlights the potential benefits of reducing oxidative stress to protect cognitive function in these patients. [Extracted from the article]