mDia2 is an important mediator of MRTF-A-dependent regulation of breast cancer cell migration (Updated July 31, 2024).

A preprint abstract from biorxiv.org discusses the role of the MRTF-SRF transcriptional complex in regulating the expressions of actin cytoskeleton-modulatory genes and its impact on breast cancer cell migration and invasion. The study demonstrates that disruption of the MRTF-SRF interaction suppresses membrane dynamics, affecting the frequency and effectiveness of membrane protrusion during cell motility. The researchers also found a positive correlation between nuclear localization of MRTF and malignant traits of cancer cells, as well as an enrichment of MRTF/SRF gene signature in distant metastases relative to primary tumors. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]