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Genetic profiling in radiotherapy: a comprehensive review.

Authors :
Rubini, Dino
Gagliardi, Federico
Menditti, Vittorio Salvatore
D'Ambrosio, Luca
Gallo, Paolo
D'Onofrio, Ida
Pisani, Antonio Rosario
Sardaro, Angela
Rubini, Giuseppe
Cappabianca, Salvatore
Nardone, Valerio
Reginelli, Alfonso
Source :
Frontiers in Oncology; 2024, p1-14, 14p
Publication Year :
2024

Abstract

This comprehensive review explores the pivotal role of radiotherapy in cancer treatment, emphasizing the diverse applications of genetic profiling. The review highlights genetic markers for predicting radiation toxicity, enabling personalized treatment planning. It delves into the impact of genetic profiling on radiotherapy strategies across various cancer types, discussing research findings related to treatment response, prognosis, and therapeutic resistance. The integration of genetic profiling is shown to transform cancer treatment paradigms, offering insights into personalized radiotherapy regimens and guiding decisions in cases where standard protocols may fall short. Ultimately, the review underscores the potential of genetic profiling to enhance patient outcomes and advance precision medicine in oncology. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2234943X
Database :
Complementary Index
Journal :
Frontiers in Oncology
Publication Type :
Academic Journal
Accession number :
178961558
Full Text :
https://doi.org/10.3389/fonc.2024.1337815