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Dual‐Stoichiometry Copper Sulphide Nanoparticles by Laser Ablation in DMSO: Synthesis and Biomedical Applications for Enhanced Photothermal Therapy and Photoacoustic Imaging.

Authors :
Taylan, Umut
Akçimen, Samet
Eş, Ismail
Küçük, Beyza Nur
Tekgül, Esra Kendir
Çelebi, Çağatay
Kumru, Yasin
Köymen, Hayrettin
Inci, Fatih
Ortaç, Bülend
Source :
ChemNanoMat; Aug2024, Vol. 10 Issue 8, p1-14, 14p
Publication Year :
2024

Abstract

Copper sulphide nanoparticles are synthesized by laser ablation of a copper target in DMSO by a 527 nm nanosecond pulsed laser. These nanoparticles have double stoichiometry (CuS and Cu1.8S) and crystalline structures, sizes under 30 nm, and they present substantial absorbance in the second near‐infrared window and photoluminescence in the visible region. The nanoparticles are used as photothermal and photoacoustic agents at 1080 nm and 1064 nm, respectively. Utilizing as a photothermal agent, these nanoparticles rapidly exhibit local heating, photothermal stability, and a temperature change of 52.2 °C within 300 s at 1 mg mL−1 concentration and 3.23 W cm−2 laser intensity. On the other hand, while employed as a photoacoustic agent, they enhanced the contrast significantly and increased the brightness proportional to their concentrations when compared to ultrasound imaging. Additionally, the biocompatibility properties of these nanoparticles were tested with cancer cells, and they were subjected to laser ablation to assess their photothermal effects. In this article, we demonstrate that copper sulphide nanoparticles synthesized by pulsed laser ablation hold great promise for photothermal and photoacoustic applications, especially in biomedical applications. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2199692X
Volume :
10
Issue :
8
Database :
Complementary Index
Journal :
ChemNanoMat
Publication Type :
Academic Journal
Accession number :
178973607
Full Text :
https://doi.org/10.1002/cnma.202400057