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Neuronal RNA processing: cross-talk between transcriptional regulation and RNA-binding proteins.
- Source :
- Frontiers in Molecular Neuroscience; 2024, p1-7, 7p
- Publication Year :
- 2024
-
Abstract
- In the nervous system, alternative RNA processing is particularly prevalent, which results in the expression of thousands of transcript variants found in no other tissue. Neuron-specific RNA-binding proteins co-transcriptionally regulate alternative splicing, alternative polyadenylation, and RNA editing, thereby shaping the RNA identity of nervous system cells. Recent evidence suggests that interactions between RNA-binding proteins and cis-regulatory elements such as promoters and enhancers play a role in the determination of neuron-specific expression profiles. Here, we discuss possible mechanisms through which transcription and RNA processing cross-talk to generate the uniquely complex neuronal transcriptome, with a focus on alternative 3'-end formation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16625099
- Database :
- Complementary Index
- Journal :
- Frontiers in Molecular Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 179015089
- Full Text :
- https://doi.org/10.3389/fnmol.2024.1426410