New Findings from Martin-Luther-University in the Area of Protein Modeling Reported (Utilization of an Optimized Alphafold Protein Model for Structure-based Design of a Selective Hdac11 Inhibitor With Anti-neuroblastoma Activity).

The article focuses on the utilization of an optimized AlphaFold protein model for structure-based design of a selective HDAC11 inhibitor with anti-neuroblastoma activity, highlighting the potential of this approach for drug discovery. Topics include the optimization of the AlphaFold model for correct prediction of folding in the absence of ligands and cofactors, the design of a new scaffold for HDAC11 inhibitors.