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Laterality, heterotaxy, and isolated congenital heart defects: The genetic basis of the segmental nature of the heart.

Authors :
Putotto, Carolina
Pugnaloni, Flaminia
Unolt, Marta
Calcagni, Giulio
Versacci, Paolo
Marino, Bruno
Source :
Genome Medicine; 8/13/2024, Vol. 16 Issue 1, p1-3, 3p
Publication Year :
2024

Abstract

To date, the role of NODAL in normal and abnormal L-R asymmetry has been well established. In a recent paper, mutations of this gene have been reported in heterotaxy but also in transposition with D- or L-ventricular loop. The effects of NODAL and other laterality genes can be recognized separately in all three cardiac segments: for topology and septation of the atria, for ventricular looping, and for spiralization and alignment of the great arteries. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1756994X
Volume :
16
Issue :
1
Database :
Complementary Index
Journal :
Genome Medicine
Publication Type :
Academic Journal
Accession number :
179038917
Full Text :
https://doi.org/10.1186/s13073-024-01375-8