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Voluntary exercise and cardiac remodeling in a myocardial infarction model.
- Source :
- Open Medicine; Jan2020, Vol. 15 Issue 1, p545-555, 11p, 2 Charts, 6 Graphs
- Publication Year :
- 2020
-
Abstract
- We investigated the effects of voluntary exercise after myocardial infarction (MI) on cardiac function, remodeling, and inflammation. Male C57BL/6J mice were divided into the following four groups: sedentary + sham (Sed-Sh), sedentary + MI (Sed-MI), exercise + sham (Ex-Sh), and exercise + MI (Ex-MI). MI induction was performed by ligation of the left coronary artery. Exercise consisting of voluntary wheel running started after the operation and continued for 4 weeks. The Ex-MI mice had significantly increased cardiac function compared with the Sed-MI mice. The Ex-MI mice showed significantly reduced expression levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and IL-10 in the infarcted area of the left ventricle compared with the Sed-MI mice. In the Ex-MI mice, the expression levels of fibrosis-related genes including collagen I and III were decreased compared to the Sed-MI mice, and the expression levels of IL-1β, IL-6, follistatin-like 1, fibroblast growth factor 21, and mitochondrial function-related genes were significantly elevated in skeletal muscle compared with the Sed mice. The plasma levels of IL-6 were also significantly elevated in the Ex-MI group compared with the Sed-MI groups. These findings suggest that voluntary exercise after MI may improve in cardiac remodeling associated with anti-inflammatory effects in the myocardium and myokine production in the skeletal muscles. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23915463
- Volume :
- 15
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Open Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 179072384
- Full Text :
- https://doi.org/10.1515/med-2020-0109