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Successful high-dose glucocorticoid therapy for anti-mitochondrial antibody-positive myocarditis arising during tocilizumab and low-dose glucocorticoid therapy for rheumatoid arthritis.
- Source :
- Immunological Medicine; Sep2024, Vol. 47 Issue 3, p200-204, 5p
- Publication Year :
- 2024
-
Abstract
- Anti-mitochondrial antibody (AMA)-positive myopathy, a recently identified condition with significant cardiac involvement, poses a serious challenge in treatment consensus due to its extreme rarity. While several studies demonstrate the efficacy of high-dose prednisolone in managing this disease, the current literature lacks substantial evidence regarding the effectiveness of biologic therapy or low-dose prednisolone for remission induction. Here, we present a case of AMA-positive myocarditis that emerged during rheumatoid arthritis treatment with tocilizumab (TCZ) and low-dose prednisolone (PSL). Successfully, intensive immunosuppressive therapy with high-dose PSL proved effective in stabilizing this condition. Our case highlights the necessity of a robust immunosuppressive approach, favoring high-dose PSL over the combination of low-dose PSL and TCZ in this disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- Volume :
- 47
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunological Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 179170337
- Full Text :
- https://doi.org/10.1080/25785826.2024.2336689