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An output-null signature of inertial load in motor cortex.
- Source :
- Nature Communications; 8/24/2024, Vol. 15 Issue 1, p1-20, 20p
- Publication Year :
- 2024
-
Abstract
- Coordinated movement requires the nervous system to continuously compensate for changes in mechanical load across different conditions. For voluntary movements like reaching, the motor cortex is a critical hub that generates commands to move the limbs and counteract loads. How does cortex contribute to load compensation when rhythmic movements are sequenced by a spinal pattern generator? Here, we address this question by manipulating the mass of the forelimb in unrestrained mice during locomotion. While load produces changes in motor output that are robust to inactivation of motor cortex, it also induces a profound shift in cortical dynamics. This shift is minimally affected by cerebellar perturbation and significantly larger than the load response in the spinal motoneuron population. This latent representation may enable motor cortex to generate appropriate commands when a voluntary movement must be integrated with an ongoing, spinally-generated rhythm. Motor cortex generates commands for voluntary movement, but its role in tasks driven by a spinal pattern generator remains unclear. Here, the authors identify a cortical signal for inertial load in locomoting mice that is decoupled from motor output. [ABSTRACT FROM AUTHOR]
- Subjects :
- MECHANICAL loads
NERVOUS system
MOVEMENT sequences
ANIMAL locomotion
FORELIMB
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 15
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- 179234468
- Full Text :
- https://doi.org/10.1038/s41467-024-51750-7