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Aurora B promotes the CENP-T–CENP-W interaction to guide accurate chromosome segregation in mitosis.
- Source :
- Journal of Molecular Cell Biology; Feb2024, Vol. 16 Issue 2, p1-13, 13p
- Publication Year :
- 2024
-
Abstract
- Accurate chromosome segregation in mitosis depends on kinetochores that connect centromeric chromatin to spindle microtubules. Centromeres are captured by individual microtubules via a kinetochore constitutive centromere-associated network (CCAN) during chromosome segregation. CCAN contains 16 subunits, including CENP-W and CENP-T. However, the molecular recognition and mitotic regulation of the CCAN assembly remain elusive. Here, we revealed that CENP-W binds to the histone fold domain and an uncharacterized N-terminal region of CENP-T. Aurora B phosphorylates CENP-W at threonine 60, which enhances the interaction between CENP-W and CENP-T to ensure robust metaphase chromosome alignment and accurate chromosome segregation in mitosis. These findings delineate a conserved signaling cascade that integrates protein phosphorylation with CCAN integrity for the maintenance of genomic stability. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16742788
- Volume :
- 16
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Molecular Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 179243289
- Full Text :
- https://doi.org/10.1093/jmcb/mjae001