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Pro- and anti-inflammatory cytokines: the hidden keys to autoimmune gastritis therapy.

Authors :
Cascetta, Greta
Colombo, Giorgia
Eremita, Gianmarco
Garcia, Joe G. N.
Lenti, Marco Vincenzo
Di Sabatino, Antonio
Travelli, Cristina
Source :
Frontiers in Pharmacology; 2024, p1-11, 11p
Publication Year :
2024

Abstract

Autoimmune gastritis (AIG) is an autoimmune disorder characterized by the destruction of gastric parietal cells and atrophy of the oxyntic mucosa which induces intrinsic factor deficiency and hypo-achlorhydria. AIG predominantly affects the antral mucosa with AIG patients experiencing increased inflammation and a predisposition toward the development of gastric adenocarcinoma and type I neuroendocrine tumors. The exact pathogenesis of this autoimmune disorder is incompletely understood although dysregulated immunological mechanisms appear to major contributors. This review of autoimmune gastritis, an unmet medical need, summarizes current knowledge on pro- and anti-inflammatory cytokines and strategies for the discovery of novel biomarkers and potential pharmacological targets. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16639812
Database :
Complementary Index
Journal :
Frontiers in Pharmacology
Publication Type :
Academic Journal
Accession number :
179288330
Full Text :
https://doi.org/10.3389/fphar.2024.1450558