Evaluation of the anodyne effect of Terminalia bellirica fruit pulp in mouse models of Swiss albino strain.

Background: Terminalia bellirica has been extensively investigated and used since time immemorial as part of Ayurvedic practice entirely because of its curable properties. Their antioxidant, hepatoprotective, antibacterial, and immune-modulatory activities are mostly attributed to the presence of glucoside, gallic acid, and its esters, chebulinic acid, etc. Aims and Objectives: The aim of the study is to analyze the effects of sub-acute administration of T. bellirica fruit pulp aqueous extract (TBFPAE) in ameliorating pain in mouse models of the Swiss albino strain. Materials and Methods: Young mice of Swiss albino strain typically 3 months' of age; Male gender and weighing approximately 20-30 g were used for the purpose of the study. The mice were investigated by grouping them into five sets of six each randomly as control, standard, and trial groups. Group I was allotted as vehicle and given 1% gum acacia (10 mL/kg) as control; Group II was given pentazocine (5 mg/kg) as standard for central anti-nociceptive activity, while the III^rd, IV^th, and V^th groups received the investigative product TBFPAE per oral in doses of 9, 18 and 36 mg/kg, respectively. Eddy's hot plate technique was employed for assessing central anodyne activity. Results: All the test groups of TBFPAE were found to have an analgesic effect but doses 18 mg/kg and 36 mg/kg demonstrated greater effects, especially at 30 and 60 min. Maximum analgesic effect with TBFPAE was seen with 36 mg/kg dose at 60 min. Conclusion: Therefore, T. bellirica has some analgesic potential. However, further studies are required to confirm its dose and usage. [ABSTRACT FROM AUTHOR]