Studies from University of Utah School of Medicine Provide New Data on Science (Structural bases for Na+-Cl- cotransporter inhibition by thiazide diuretic drugs and activation by kinases).

A recent study from the University of Utah School of Medicine has provided new data on the structural bases for the inhibition and activation of the Na+-Cl- cotransporter (NCC) by thiazide diuretic drugs and kinases. The NCC plays a crucial role in balancing electrolytes and blood pressure by driving salt reabsorption in the kidney. Thiazide diuretics have been used since the 1950s to treat hypertension and edema by inhibiting NCC-mediated renal salt retention. The study revealed the structural interactions between the thiazide drugs and NCC, as well as the phosphorylation-dependent allosteric network that influences NCC ion translocation. For more information, the full article can be accessed for free at the Nature Communications website. [Extracted from the article]