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An overview of early genetic predictors of IgA deficiency.
- Source :
- Expert Review of Molecular Diagnostics; Aug2024, Vol. 24 Issue 8, p715-727, 13p
- Publication Year :
- 2024
-
Abstract
- Introduction: Inborn errors of immunity (IEIs) refer to a heterogeneous category of diseases with defects in the number and/or function of components of the immune system. Immunoglobulin A (IgA) deficiency is the most prevalent IEI characterized by low serum level of IgA and normal serum levels of IgG and/or IgM. Most of the individuals with IgA deficiency are asymptomatic and are only identified through routine laboratory tests. Others may experience a wide range of clinical features including mucosal infections, allergies, and malignancies as the most important features. IgA deficiency is a multi-complex disease, and the exact pathogenesis of it is still unknown. Areas covered: This review compiles recent research on genetic and epigenetic factors that may contribute to the development of IgA deficiency. These factors include defects in B-cell development, IgA class switch recombination, synthesis, secretion, and the long-term survival of IgA switched memory B cells and plasma cells. Expert opinion: A better and more comprehensive understanding of the cellular pathways involved in IgA deficiency could lead to personalized surveillance and potentially curative strategies for affected patients, especially those with severe symptoms. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14737159
- Volume :
- 24
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Expert Review of Molecular Diagnostics
- Publication Type :
- Academic Journal
- Accession number :
- 179338720
- Full Text :
- https://doi.org/10.1080/14737159.2024.2385521