Sun Yat-Sen University Researchers Update Understanding of Ischemia (Suppression of inner blood-retinal barrier breakdown and pathogenic Muller glia activation in ischemia retinopathy by myeloid cell depletion).

Researchers from Sun Yat-Sen University have conducted a study on ischemic retinopathies, including diabetic retinopathy, which are major causes of vision loss. The study focused on the breakdown of the inner blood-retinal barrier (BRB) and the activation of Muller glia in ischemic disease. The researchers used a CSF-1R inhibitor to deplete microglia in the retina and found that this treatment suppressed the activation of microglia and infiltration of macrophages, leading to a reduction in BRB breakdown. The study also demonstrated the role of myeloid cells in the dysregulation of the inner BRB and the amplification of neuroinflammation by Muller glia. [Extracted from the article]