Researchers from University of Kentucky Publish New Studies and Findings in the Area of Life Sciences (The Uncoupling Effect of 17b-Estradiol Underlies the Resilience of Female-Derived Mitochondria to Damage after Experimental TBI).

A recent study conducted by researchers at the University of Kentucky explores the differences in outcomes between males and females after traumatic brain injury (TBI). The study suggests that estrogen may play a role in promoting mitochondrial protection following TBI. The researchers found that treatment with 17b-estradiol (E2) improved mitochondrial function in mice after experimental TBI. These findings highlight the importance of studying mitochondrial dysfunction in both sexes after TBI and suggest a potential neuroprotective mechanism for E2 in attenuating mitochondrial dysfunction. [Extracted from the article]