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Study Results from Washington State University in the Area of Life Science Reported (Developmental Expression of Drug Transporters and Conjugating Enzymes Involved In Enterohepatic Recycling: Implication for Pediatric Drug Dosing).

Source :
Pediatrics Week; 9/13/2024, p3520-3520, 1p
Publication Year :
2024

Abstract

A study conducted by researchers at Washington State University highlights the need for more research on the safety and efficacy of drugs used in children. The study found that around 50% of drugs used in children have not been adequately tested for this population. The researchers used physiologically-based pharmacokinetic modeling to predict drug pharmacokinetics in children, taking into account age-dependent differences in drug-metabolizing enzymes and transporters. The study concluded that incorporating age-dependent abundance data in pharmacokinetic models can improve pediatric dose prediction and lead to safer drug therapy for children. [Extracted from the article]

Details

Language :
English
ISSN :
19442637
Database :
Complementary Index
Journal :
Pediatrics Week
Publication Type :
Periodical
Accession number :
179472082