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Study Results from Washington State University in the Area of Life Science Reported (Developmental Expression of Drug Transporters and Conjugating Enzymes Involved In Enterohepatic Recycling: Implication for Pediatric Drug Dosing).
- Source :
- Pediatrics Week; 9/13/2024, p3520-3520, 1p
- Publication Year :
- 2024
-
Abstract
- A study conducted by researchers at Washington State University highlights the need for more research on the safety and efficacy of drugs used in children. The study found that around 50% of drugs used in children have not been adequately tested for this population. The researchers used physiologically-based pharmacokinetic modeling to predict drug pharmacokinetics in children, taking into account age-dependent differences in drug-metabolizing enzymes and transporters. The study concluded that incorporating age-dependent abundance data in pharmacokinetic models can improve pediatric dose prediction and lead to safer drug therapy for children. [Extracted from the article]
- Subjects :
- LIFE sciences
SCIENCE journalism
CLINICAL pharmacology
DRUG therapy
COENZYMES
Subjects
Details
- Language :
- English
- ISSN :
- 19442637
- Database :
- Complementary Index
- Journal :
- Pediatrics Week
- Publication Type :
- Periodical
- Accession number :
- 179472082