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Metastatic extraneural glioblastoma diagnosed with molecular testing.

Authors :
Majd, Nazanin K
Vo, Henry Hiep
Moran, Cesar A
Weathers, Shiao-Pei
Song, I-Wen
Williford, Garret L
Rodon, Jordi
Fu, Siqing
Tsimberidou, Apostolia-Maria
Source :
Oncologist; Sep2024, Vol. 29 Issue 9, p811-816, 6p
Publication Year :
2024

Abstract

Glioblastoma, the most common malignant brain tumor in adults, is associated with a median overall survival duration of less than 2 years. Extraneural metastases occur in less than 1% of all patients with glioblastoma. The mechanism of extraneural metastasis is unclear. We present a case of extensive extraneural, extraosseous, epidural, and soft-tissue metastasis of glioblastoma. The diagnosis of metastatic glioblastoma was made only after next-generation sequencing (NGS) of the metastatic paraspinal lesions was completed. The CDK4, pTERT, PTEN, and TP53 molecular alterations seen in the initial intracranial glioblastoma were found in the paraspinal tumor, along with the addition of MYC, which is implicated in angiogenesis and epidermal-to-mesenchymal transition. Immunohistochemical stains showed that neoplastic cells were negative for GFAP. In conclusion, this case raises awareness about the role of NGS in the diagnosis of extraneural glioblastoma. This diagnosis was not possible with histology alone and only became evident after molecular profiling of the metastatic lesions and its comparison to the original tumor. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10837159
Volume :
29
Issue :
9
Database :
Complementary Index
Journal :
Oncologist
Publication Type :
Academic Journal
Accession number :
179552555
Full Text :
https://doi.org/10.1093/oncolo/oyae115