Studies Conducted at Jiangsu Institute of Nuclear Medicine on Biomimetics Recently Reported (Imaging Identifies Superior Inflammation Targeting of M1 Macrophages for Cryo-shocked Cell Pulmonary Drug Delivery To Treat Acute Lung Injury).

Researchers at the Jiangsu Institute of Nuclear Medicine in Wuxi, China have developed a biomimetic drug delivery system using cryo-shocked macrophages to treat acute lung injury (ALI). Macrophages play a crucial role in treating ALI, but traditional treatments like systemic administration of glucocorticoids have severe side effects. The researchers used positron emission tomography (PET) imaging to demonstrate the superior targeting abilities of live M1 macrophages in homing in on local inflammatory foci. By engineering liquid nitrogen-treated (LNT) M1 macrophages, they were able to deliver glucocorticoids directly to inflamed lung tissues, reducing inflammation and minimizing systemic drug exposure. This innovative approach shows promise as a safe and potent treatment for ALI. [Extracted from the article]