Back to Search
Start Over
Comparing the Efficacy of Probiotic Nutraceuticals and Probiotic Food (Curd) in Combination with Antidepressants for Depression.
- Source :
- Archives of Medicine & Health Sciences; May-Aug2024, Vol. 12 Issue 2, p176-180, 5p
- Publication Year :
- 2024
-
Abstract
- Background and Aim: Depression is a widespread mental health condition with a significant global impact. Recent research has explored the gut--brain axis, emphasizing the role of microbiota in neurotransmitter production. This study aims to explore the effectiveness of two complementary probiotic interventions: probiotic-rich curd and probiotic capsules, used in combination with the antidepressant escitalopram over 4 weeks. The primary objectives include assessing their impact on reducing the severity of depression, comparing their effectiveness, and discussing the clinical implications of findings. Materials and Methods: We conducted a 4-week prospective observational study at the Department of Psychiatry, MGM Medical College, and the associated Mental Hospital in Indore. Ninety individuals aged 18-60, diagnosed with depression (International Classification of Diseases-10) and assessed using the Hamilton Depression Rating Scale, participated. Subjects were divided into three groups: escitalopram 10 mg (n = 30), escitalopram 10 mg + 120 mL curd (n = 30), and escitalopram 10 mg + probiotic capsule (n = 30). Assessments were conducted on days 0, 14, and 28 using the Hamilton Depression Rating Scale. Results: All treatment groups exhibited a significant reduction in mean Hamilton Depression Rating Scale scores over the study duration (P < 0.001). Notably, the probiotic group showed a slightly greater reduction in scores between day 0 and day 28 compared to the curd and escitalopram-only groups. Conclusion: The study demonstrates the potential for slightly better outcomes with probiotic interventions alongside the antidepressant escitalopram over 4 weeks. Beyond symptom relief, this approach may offer lower side effects, potentially enhancing patient adherence. Future research should investigate long-term effects and specific probiotic strains in a larger, diverse population. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of probiotics
PREVENTION of mental depression
PATIENT compliance
DATA analysis
YOGURT
CLINICAL trials
SCIENTIFIC observation
BRAIN
SAMPLE size (Statistics)
FUNCTIONAL foods
TREATMENT effectiveness
DESCRIPTIVE statistics
GASTROINTESTINAL system
HUMAN microbiota
CHI-squared test
AGE distribution
LONGITUDINAL method
HAMILTON Depression Inventory
COMBINED modality therapy
RESEARCH
STATISTICS
CITALOPRAM
COMPARATIVE studies
DATA analysis software
MENTAL depression
PHARMACEUTICAL encapsulation
NOSOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 23214848
- Volume :
- 12
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Archives of Medicine & Health Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 179623608
- Full Text :
- https://doi.org/10.4103/amhs.amhs_246_23